Recent advances in neuroscienti?c understanding make parallel computing devices modeled after the human neocortex a plausible, attractive, fault-tolerant, and energy-ef?cient possibility. Such attributes have once again sparked an interest in creating learning algorithms that aspire to reverse-engineer many of the abilities of the brain. In this paper we describe a GPGPU-accelerated extension to an intelligent learning model inspired by the structural and functional properties of the mammalian neocortex. Our cortical network, like the brain, exhibits massive amounts of processing parallelism, making today’s GPGPUs a highly attractive and readily-available hardware accelerator for such a model. Furthermore, we consider two inef?ciencies inherent to our initial design: multiple kernel-launch overhead and poor utilization of GPGPU resources. We propose optimizations such as a software work-queue structure and pipelining the hierarchical layers of the cortical network to mitigate such problems. Our analysis provides important insight into the GPU architecture details including the number of cores, the memory system, and the global thread scheduler. Additionally, we create a runtime pro?ling tool for our parallel learning algorithm which proportionally distributes the cortical network across the host CPU as well as multiple GPUs, whether homogeneous or heterogeneous, that may be available to the system. Using the pro?ling tool with these optimizations on Nvidia’s CUDA framework, we achieve up to 60x speedup over a singlethreaded CPU implementation of the model.